Clinical Trials

This randomized phase II/III trial studies how well cediranib maleate and olaparib work when given together or separately, and compares them to standard chemotherapy in treating patients with ovarian, fallopian tube, or primary peritoneal cancer that has returned after receiving chemotherapy with drugs that contain platinum (platinum-resistant) or continued to grow while being treated with platinum-based chemotherapy drugs (platinum-refractory). Cediranib maleate and olaparib may stop the growth of tumor cells by blocking enzymes needed for cell growth. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether giving cediranib maleate and olaparib together may cause more damage to cancer cells when compared to either drug alone or standard chemotherapy.

MMC - Marshfield

1000 N OAK AVE

MARSHFIELD, WI 54449

MMC - Minocqua

9576 Highway 70

MINOCQUA, WI 54548

MMC - Rice Lake

1700 W STOUT ST

RICE LAKE, WI 54868

MMC - River Region at Stevens Point

4100 State Highway 66

Stevens Point, WI 54482

MMC - Weston

3400 Ministry Parkway

WESTON, WI 54476

zzzMfld Clinic Cancer Care at Sacred Heart Hospita

900 W CLAIREMONT AVE

EAU CLAIRE, WI 54701

We hypothesize that the property of ovarian tumors to raise serum calcium and lower serum albumin can be exploited to detect ovarian cancer earlier in their natural history. We will test that hypothesis in a case-control study in which changes in serum calcium and albumin levels in the medical records of women with ovarian cancer are compared to those of control women without ovarian cancer over several years. We hypothesize that relative to controls, women with ovarian cancer will show a significant increase (positive slope) in their albumin-adjusted calcium levels and a negative slope in their total albumin levels. In normal women, total calcium levels fluctuate only about 2% during their lifetime . Thus a pattern of rising calcium is abnormal (and is otherwise uncommon). Moreover, this pattern of rising calcium and declining albumin should be identified readily by a computer algorithm. A second objective of this study is to produce an algorithm that would ¿flag¿ women with this pattern. These women could be referred for increased ovarian cancer surveillance, leading to earlier detection of ovarian cancer. Thus, our Specific Aims are to: 1. Test the hypothesis that, compared to women who do not have a diagnosis of ovarian cancer, women with a diagnosis of ovarian cancer will show a significant increase in their serum albumin-adjusted calcium and serum albumin. If observed, we will develop a computer algorithm that describes this trend in calcium/albumin and enables the prediction of ovarian cancer. 2. Because ovarian cancer is associated with reduced hepatic synthesis of albumin, we will explore whether the addition of data regarding other liver enzymes, e.g., alkaline phosphatase and ALT (also available from the CMP), can aid in the discrimination of ovarian cancer. This exploratory aim is justifiable because multiple reports indicate that alkaline phosphatase levels are increased in sera and in ovarian tissue from women with ovarian cancer , .

MMC - Marshfield

1000 N OAK AVE

MARSHFIELD, WI 54449

The purpose of this study is to compare the effects on low risk breast cancer receiving usual care that includes regional radiation therapy, with receiving no regional radiation therapy. Researchers want to see if not giving this type of radiation treatment works as well at preventing breast cancer from coming back.

MMC - Eau Claire Cancer Center

2200 Craig Road

Eau Claire, WI 54701

MMC - Marshfield

1000 N OAK AVE

MARSHFIELD, WI 54449

MMC - Minocqua

9576 Highway 70

MINOCQUA, WI 54548

MMC - Rice Lake

1700 W STOUT ST

RICE LAKE, WI 54868

MMC - River Region at Stevens Point

4100 State Highway 66

Stevens Point, WI 54482

zzzDiagnostic & Treatment Center

3401 CRANBERRY BLVD

WESTON, WI 54476

The purpose of this study is to evaluate whether a BP treatment strategy to achieve targets that are beneficial for non-pregnant adults (<140/90 mmHg) is safe and effective during pregnancy.

MMC - Marshfield

1000 N OAK AVE

MARSHFIELD, WI 54449

The objective of this protocol is to allow the use of cisapride by patients with GERD, gastroparesis, pseudo-obstruction or severe chronic constipation disorders who have failed standard therapy.

MMC - Marshfield

1000 N OAK AVE

MARSHFIELD, WI 54449

MMC - Minocqua

9576 Highway 70

MINOCQUA, WI 54548

zzzPark Falls Center

50 SHERRY AVE

PARK FALLS, WI 54552

Melissa Slager & Angela Varsho

MMC - Marshfield

1000 N OAK AVE

MARSHFIELD, WI 54449

Implement a screening tool in NCORP to collect broader demographic and clinical data to generate hypothesis and research questions in the following areas of research: cancer screening, cancer prevention, symptom science, cancer care disparities, comparative effectiveness and cancer care delivery research.

MC - Chippewa Falls Center

2655 CTY HWY I

CHIPPEWA FALLS, WI 54729

MC - Wausau Center

2727 PLAZA DRIVE

WAUSAU, WI 54401

MC - Wisconsin Rapids Center

220 24TH ST SOUTH

WISCONSIN RAPIDS, WI 54494

MMC - Ladysmith

906 College Ave W

Ladysmith, WI 54848

MMC - Marshfield

1000 N OAK AVE

MARSHFIELD, WI 54449

MMC - Minocqua

9576 Highway 70

MINOCQUA, WI 54548

MMC - Rice Lake

1700 W STOUT ST

RICE LAKE, WI 54868

MMC - Weston

3400 Ministry Parkway

WESTON, WI 54476

zzzMarshfield Clinic Cancer Care At St Michaels

900 ILLINOIS AVE

STEVENS POINT, WI 54481

zzzMfld Clinic Cancer Care at Sacred Heart Hospita

900 W CLAIREMONT AVE

EAU CLAIRE, WI 54701

This subprotocol (EAY131-M) should be used in conjunction with the MATCH Master Protocol (EAY131).

MC - Wausau Center

2727 PLAZA DRIVE

WAUSAU, WI 54401

MMC - Marshfield

1000 N OAK AVE

MARSHFIELD, WI 54449

MMC - Minocqua

9576 Highway 70

MINOCQUA, WI 54548

MMC - Rice Lake

1700 W STOUT ST

RICE LAKE, WI 54868

MMC - River Region at Stevens Point

4100 State Highway 66

Stevens Point, WI 54482

MMC - Weston

3400 Ministry Parkway

WESTON, WI 54476

zzzMarshfield Medical Center

611 Saint Joseph Ave

Marshfield, WI 54449

zzzMfld Clinic Cancer Care at Sacred Heart Hospita

900 W CLAIREMONT AVE

EAU CLAIRE, WI 54701

HUD authorized by Federal Law for use with neurovascular embolic coils in patients >18 years of age for the treatment of unruptured wide-necked intracranial aneurysms with neck widths of > 4mm or dome to neck ratio < 2 originating on or near a vessel bifurcation of the basilar tip or carotid terminus, with at least a portion of the aneurysm neck overlapping the lumen of the parent artery.

MC - Chippewa Falls Center

2655 CTY HWY I

CHIPPEWA FALLS, WI 54729

MC - Wausau Center

2727 PLAZA DRIVE

WAUSAU, WI 54401

MC - Wisconsin Rapids Center

220 24TH ST SOUTH

WISCONSIN RAPIDS, WI 54494

MMC - Marshfield

1000 N OAK AVE

MARSHFIELD, WI 54449

MMC - Minocqua

9576 Highway 70

MINOCQUA, WI 54548

MMC - Rice Lake

1700 W STOUT ST

RICE LAKE, WI 54868

MMC - Weston

3400 Ministry Parkway

WESTON, WI 54476

zzzLadysmith Dental Clinic

315 MINER AVE WEST

LADYSMITH, WI 54848

zzzLakeview Medical Center

1700 West Stout Street

Rice Lake, WI 54868

zzzMarshfield Clinic At James Beck Cancer Center

2251 NORTH SHORE DR

RHINELANDER, WI 54501

zzzMarshfield Clinic Cancer Care At St Michaels

900 ILLINOIS AVE

STEVENS POINT, WI 54481

zzzMfld Clinic Cancer Care at Sacred Heart Hospita

900 W CLAIREMONT AVE

EAU CLAIRE, WI 54701

To compare the proportions of participants in the Tomosynthesis (TM) and Digital Mammography (DM) study arms experiencing the occurrence of an advanced breast cancer at any time during a period of 4.5 years from randomization,including the period of active screening and a period of clinical follow-up after the last screen (T4).

MMC - Marshfield

1000 N OAK AVE

MARSHFIELD, WI 54449